Agent Name
o-Phenylenediamine
Major Category
Nitrogen Compounds
Synonyms
1,2-Benzenediamine; 1,2-Diaminobenzene; 1,2-Fenylendiamin [Czech] 1,2-Benzenediamine; 1,2-Diaminobenzene; 1,2-Fenylendiamin [Czech]; 1,2-Phenylenediamine; 2-Aminoaniline; C.I. 76010; C.I. Oxidation Base 16; CI 76010; CI Oxidation Base 16; OPDA; Orthamine; PODA; SQ 15500; o-Benzenediamine; o-Diaminobenzene; o-Fenylendiamin [Czech]; [ChemIDplus] UN1673
Category
Amines, Aromatic
Description
Colorless to brownish-yellow solid that darkens on exposure to light and air; [CHEMINFO]
Sources/Uses
Used as a chemical intermediate, analytical reagent, and photographic developer; [CHEMINFO]
Comments
At lethal concentrations, exposed animals have seizures and paralysis without anesthesia. [ChemIDplus] Methemoglobinemia is observed in acute animal studies. In subchronic studies, rats have anemia and elevated liver enzymes. "Critical Effects" are irritation; liver; blood; [ACGIH]
Skin Designation (ACGIH)
Insufficient data
Lethal Concentration
LC50 (rat) = 1,873 mg/m3
Explanatory Notes
Melting point = 219 deg F; [CAMEO]
Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Possible (2b)
ACGIH Carcinogen
Confirmed Animal
Processes
Industrial Processes with risk of exposure: