12-O-Tetradecanoylphorbol-13-acetate
Agent Name
12-O-Tetradecanoylphorbol-13-acetate
CAS Number
16561-29-8
Formula
C36-H56-O8
Major Category
Other Uses
Category
Biochemical Research
Description
White solid; [CAMEO] Colorless powder; [Sigma-Aldrich MSDS]
Sources/Uses
Highly effective tumor promoter found in croton oil that stimulates DNA and RNA synthesis; [ChemIDplus] Used in cancer research for studying tumor promotion mechanisms, screening for potential inhibiting agents, and as a positive control for tumor promoting agents; [HSDB]
Comments
Effects numerous cellular functions including inhibition and stimulation growth and function, increased membrane transport of hexose, decreased ovarian and testicular steroidogenesis, interferon-like activity, enhanced capacitation of sperm, and tumor promotion; Embryotoxicity and teratogenicity observed in rodents; [REPROTOX] A skin irritant; A strong purgative by ingestion; [NTP] A skin irritant; Targets the bone marrow, lungs, gastrointestinal tract, blood, and skin; [Sigma-Aldrich MSDS]
Biomedical References
Adverse Effects
Reproductive Toxin
Yes
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.