Terpineol

Synonyms

Terpineols; [ChemIDplus] Terpineol lilla; [IUCLID] Terpineol, natural; Terpineol mixed isomers; [Sigma-Aldrich MSDS]

Category

Wood Dusts & Extracts

Description

Liquid; [Sigma-Aldrich MSDS]

Sources/Uses

Found as alpha, beta, and gamma isomers; The alpha isomer is obtained from pine needles and used in perfumes, cosmetics, and flavorings; [REPROTOX] Used in the chemical and personal-domestic use industries, as a cleaning/washing agent, disinfectant, food additive, odor agent, and in cosmetics; [IUCLID] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Comments

A moderate skin irritant in rabbits; Not sensitizing in guinea pig maximization test; No evidence of skin sensitization in studies of 25 (12% in petrolatum) and 37 (12.5% in ethanol) volunteers; [IUCLID] Up to ten positive patch test reactions in studies of at least 1,000 patients for fragrance allergies; [EC: SCCS] No evidence of skin sensitization in experimental animals; The liver was show to be the target organ of toxicity in 5-week study of rats (fully recovered after 2 weeks); Significantly reduced testis weights and possibly epididymal weights also observed at 750 mg/kg/day; No evidence of reproductive or developmental toxicity; [EPA - TSCATS] Included in list of "established contact allergens in humans"; [EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] An irritant; [Sigma-Aldrich MSDS] See "alpha-Terpineol."

Biomedical References

0.031 mm Hg

LC50 (rat) > 4,760 mg/m3/4hr

Yes

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Using Disinfectants or Biocides