Simazine

Synonyms

1-Chloro-3,5-bis(ethylamino)-2,4,6-triazine; 2,4-Bis(aethylamino)-6-chlor-1,3,5-triazin [German]; 2,4-Bis(ethylamino)-6-chloro-s-triazine; 2-Chloro-4,6-bis(ethylamino)-1,3,5-triazine; 2-Chloro-4,6-bis(ethylamino)-s-triazine; 6-Chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine; 6-Chloro-N2,N4-diethyl-1,3,5-triazine-2,4-diamine; A 2079; AI3-51142; Aktinit S; Amizine; Aquazine; Azotop; Batazina; Batazine FLO; Bitemol; Bitemol S 50; CAT; CAT (herbicide); CDT; CET; Cekusan; Cekusima; Cekuzina-S; G 27692; G-27692; Geigy 27,692; Gesapun; Gesaran; Gesatop; Gesatop 50; H 1803; Herbatoxol S; Herbazin; Herbazin 50; Herbex; Herbex (pesticide); Herboxy; Hungazin DT; Premazine; Primatel S; Primatol S; Princep; Printop; Radocon; Radokor; Simadex; Simanex; Simatsin-neste; Simazin; Simazine; Simazine 80W; Symazine; Tafazine; Tafazine (VAN); Tafazine 50-W; Taphazine; Triazine A 384; W 6658; Yrodazin; Zeapur; [ChemIDplus]

Category

Herbicides, Triazine

Description

Colorless to white crystals; [EXTOXNET]

Sources/Uses

Used as a broadleaf herbicide; [EXTOXNET] Inhibits photosynthesis in weeds after application to soil; Used in crops (apples, oranges, almonds, corn), lawns, and in ponds and aquariums (algicide); [ACGIH]

Comments

"Simazine is slightly to practically nontoxic." Damage to the liver and other organs is observed in high-dose feeding studies of experimental animals. [EXTOXNET] The following herbicides have an oral LD50 of >1 gm/kg and have little or no acute toxicity in humans: Alachlor, Amitrole, Ammonium sulfamate, Atrazine, Dalapon, Dicamba, Glyphosphate, Monuron, Oryzalin, Picloram, Propanil, Simazine, etc. [LaDou, p. 613] For the triazine herbicides, systemic toxicity unlikely unless large amounts are ingested; May cause irritation; [EPA Pesticides, p. 121] Not acutely toxic; TLV Basis: hematologic effects; "In female rats, depression in red blood cell count, hemoglobin and hematocrit and elevations in mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and white blood cell count were seen at both the mid and high doses and the NOEL for these effects was 10 ppm or 0.52 mg/kg/day." Dermatitis has been reported, "but a repeated patch insult test with 50 human subjects showed the 80% wettable powder formulation of simazine was not a primary irritant, defatting agent, or sensitizer." [ACGIH]

Reference Link #1

Biomedical References

Insufficient data

0.5 mg/m3, inhalable particulate matter

2.21E-08 mm Hg

LC50 (rat) = 9800 mg/m3/4H

Reference Link #2

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Confirmed Animal

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)