Major Category
Biological Agents
Synonyms
Thrombin human; Thrombin, topical; Blood-coagulation factor II, activated; Blood-coagulation factor IIa; Bovine thrombin; Evithrom; Factor IIa; Fibrinogenase; Recothrom; Thrombase; Thrombin II; Thrombin JMI; Thrombin, topical (recombinant); Thrombin-C; Thrombinar; Thrombofort; Thrombostat; Tropostasin; [ChemIDplus] Thrombin, from bovine plasma; [Sigma-Aldrich MSDS]
Description
White powder; [Sigma-Aldrich MSDS]
Sources/Uses
Important enzyme in coagulation, produced from prothrombin at the bleeding site; Used as a local hemostatic; [Merck Index] Used in enzyme preparations for binding reconstituted meat; [ExPub: EC: EFSA] "Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions." [Wikipedia]
Comments
A skin and strong eye irritant; May cause skin and respiratory sensitization; Targets the vascular system; [Sigma-Aldrich MSDS] See "ENZYMES."
Diseases
Occupational diseases associated with exposure to this agent: