Imidazole
Agent Name
Imidazole
CAS Number
288-32-4
Formula
C3-H4-N2
Major Category
Nitrogen Compounds
Synonyms
1,3-Diaza-2,4-cyclopentadiene; 1,3-Diazole; Formamidine, N,N'-vinylene-; Glioksal [Polish]; Glyoxalin; Glyoxaline; IMD; Imidazol; Iminazole; Imutex; Methanimidamide, N,N'-1,2-ethenediyl-; Miazole; Pyrro(b)monazole; 1H-Imidazole; [ChemIDplus] N,N'-Vinylene-formadine; [REPROTOX] UN3263
Category
Imidazoles
Description
Solid; [Merck Index] Colorless to yellow solid with an amine-like odor; [OECD SIDS] White or light yellow crystals; [Sigma-Aldrich MSDS]
Sources/Uses
Used as an intermediate (pharmaceuticals, pesticides, dye intermediates, auxiliaries for textile dyeing and finishing, photographic chemicals, and corrosion inhibitors) and hardener for epoxy resins; Also used in process regulators, anti-freeze agents, photographic applications, laboratory applications, glues/adhesives, cement fillers or sealing compounds, paints, varnishes, lacquers, consumer cleaning and washing agents, swimming pool applications, and in publishing, printing, and reproduction of recorded media; [OECD SIDS]
Comments
Corrosive to skin and irritating to eyes in rabbits--may cause permanent eye injury; A 90-day oral study of rats showed histopathological changes of the liver and kidney at 180 mg/kg/day; No evidence of neurotoxicity; No effects on sperm parameters or toxicity to male or female reproductive organs observed in the 90-day study; Teratogenicity and developmental toxicity observed at doses maternally toxic in rats; [OECD SIDS] No increase in abnormalities of offspring in rats dosed 240 mg/kg by gavage during embryogenesis (non-standard study, no information on maternal toxicity); [REPROTOX] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; May be toxic to human reproduction and cause harm to the unborn child; [Sigma-Aldrich MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
0.002 mm Hg
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Corrosive solid, basic, organic, n.o.s."
Adverse Effects
Toxic Pneumonitis
Yes
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: