Dipropylene glycol monoethyl ether

Synonyms

DPGEE; [Glycol Ethers Online] Propanol, (2-ethoxymethylethoxy)-; [ChemIDplus] Propanol, 2-ethoxy-methylethoxy; [ECETOC]

Category

Glycol Ethers (P Series)

Sources/Uses

Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Comments

A mild eye irritant in rabbits; Not a skin sensitizer in guinea pigs using the Magnusson and Kligman method; Exposure to saturated vapor concentration (estimated at 2,410 mg/m3) for 7 hours resulted in eye and nasal irritation, transient weight loss, and mortality in 1 of 12 rats exposed; Survivors recovered fully in 24 hours; Increased liver weights without corresponding histopathology and minimal to minor hyaline droplet formation in the proximal tubular cells in kidneys of males observed in 4-week oral study of rats at 1,000 mg/kg/day; Increased liver and kidney (males) weights with histopathological changes observed in 13-week oral study of rats at 250 and 1,000 mg/kg/day; No effects noted in the functional observation batteries or on hematological parameters; A 1-generation study of rats produced NOAELs for parents and reproductive toxicity of the highest tested dose (1,000 mg/kg/day); Single oral doses of 4.7 mg/kg caused symptoms consistent with CNS depression in rats; [ECETOC]

Biomedical References

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect