2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate

Synonyms

Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-); 2-HBTU; [ChemIDplus] HBTU; 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate (1-) (1:1); N-HBTU; [Merck Index] O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate; [Sigma-Aldrich]

Category

Triazoles

Description

White solid; [Merck Index] White crystals; [Sigma-Aldrich]

Sources/Uses

Used as a coupling reagent in synthetic organic chemistry (peptide synthesis); [Merck Index] For laboratory research; [Sigma-Aldrich]

Comments

Occupational asthma confirmed in a laboratory technician exposed to peptide coupling reagents (TBTU and HBTU); [Malo] Moderate skin, eye, and respiratory irritant; [Sigma-Aldrich]

Biomedical References

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational