1,3-Diisopropylcarbodiimide
Agent Name
1,3-Diisopropylcarbodiimide
Major Category
Nitrogen Compounds
Synonyms
Diisopropylcarbodiimide; N,N'-Diisopropylcarbodiimide; N,N'-Methanetetraylbis-2-propanamine; 2-Propanamine, N,N'-methanetetraylbis-; Carbodiimide, diisopropyl-; N,N'-Methanetetraylbis(1-methylethylamine); [ChemIDplus] DIPC; DIC; [Merck Index] UN2929
Category
Other Nitrogen Compounds
Description
Colorless liquid; [Merck Index]
Sources/Uses
Used as a reagent in synthetic organic chemistry; [Merck Index] Used as a chemical intermediate and as a stabilizer for Sarin (chemical weapon); [HSDB]
Comments
An irritant; May cause skin and respiratory sensitization; [Merck Index] No evidence of carcinogenicity in dermal studies of mice and rats; Clinical and histological evidence of neurotoxicity observed in male rats; [NTP] A mild skin irritant; Causes cutaneous sensitization, convulsions, coma, lachrymation, ataxia, changes in thymus and kidney weights, weight loss, spermatogenesis, and allergic dermatitis in repeated-dose dermal studies of mice; [RTECS] Reacts with water producing 1,3-diisopropylurea; [HSDB] An irritant that may cause serious eye injury; May cause skin and respiratory sensitization; Highly toxic by inhalation; [Alfa Aesar MSDS]
Vapor Pressure
9.79 mm Hg
Lethal Concentration
LC50 (rat) = 105 mg/m3/4hr
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxic liquid, flammable, organic, n.o.s."
Neurotoxin
Other CNS neurotoxin
Diseases
Occupational diseases associated with exposure to this agent: