1,3-Diisopropylcarbodiimide

Synonyms

Diisopropylcarbodiimide; N,N'-Diisopropylcarbodiimide; N,N'-Methanetetraylbis-2-propanamine; 2-Propanamine, N,N'-methanetetraylbis-; Carbodiimide, diisopropyl-; N,N'-Methanetetraylbis(1-methylethylamine); [ChemIDplus] DIPC; DIC; [Merck Index] UN2929

Category

Other Nitrogen Compounds

Description

Colorless liquid; [Merck Index]

Sources/Uses

Used as a reagent in synthetic organic chemistry; [Merck Index] Used as a chemical intermediate and as a stabilizer for Sarin (chemical weapon); [HSDB]

Comments

An irritant; May cause skin and respiratory sensitization; [Merck Index] No evidence of carcinogenicity in dermal studies of mice and rats; Clinical and histological evidence of neurotoxicity observed in male rats; [NTP] A mild skin irritant; Causes cutaneous sensitization, convulsions, coma, lachrymation, ataxia, changes in thymus and kidney weights, weight loss, spermatogenesis, and allergic dermatitis in repeated-dose dermal studies of mice; [RTECS] Reacts with water producing 1,3-diisopropylurea; [HSDB] An irritant that may cause serious eye injury; May cause skin and respiratory sensitization; Highly toxic by inhalation; [Alfa Aesar MSDS]

Biomedical References

9.79 mm Hg

LC50 (rat) = 105 mg/m3/4hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic liquid, flammable, organic, n.o.s."

Yes

Yes

Other CNS neurotoxin

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Contact dermatitis, allergic