Isatin

Synonyms

2,3-Diketoindoline; 2,3-Dioxo-2,3-dihydroindole; 2,3-Dioxoindoline; 2,3-Indolinedione; Isatic acid lactam; Isatine; Isatinic acid anhydride; Isotin; o-Aminobenzoylformic anhydride; Pseudoisatin; 1H-Indole-2,3-dione; Indole-2,3-dione; Indoline-2,3-dione; [ChemIDplus] Indolinedione-2,3; [EC: SCCP]

Category

Indoles

Description

Orange solid; [Merck Index] Orange odorless powder; [Alfa Aesar MSDS]

Sources/Uses

Used to make vat dyes and in analytical chemistry as a reagent for cuprous ions, mercaptans, thiophene, and indican; [Merck Index] Used in hair coloring products; [EC: SCCP]

Comments

Not a skin or eye irritant in rabbits; A very potent skin sensitizer in guinea pig maximization study; No evidence of contact allergy in Buehler study of guinea pigs (considered inconclusive due to orange/red staining at application sites); Delayed contact hypersensitivity observed in local lymph node assay (LLNA) studies of mice; Teratogenicity observed in the presence of maternal toxicity in rats; [EC: SCCP] Causes flaccid paralysis without anesthesia (usually neuromuscular blockage) and changes in motor activity in oral and intravenous lethal-dose studies of rats; Causes pigmented or nucleated red blood cells and changes in erythrocyte count in 6-week oral studies of rats; [RTECS] May cause eye irritation; Reproductive effects observed in experimental animals; [Alfa Aesar MSDS]

Biomedical References

1.11E-05 mm Hg

LC50 (rat) > 5,200 mg/m3/4hr

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Dressing Hair