6-tert-Butyl-2,4-xylenol

Synonyms

2,4-Dimethyl-6-tert-butylphenol; 2-tert-Butyl-4,6-dimethylphenol; 6-t-Butyl-2,4-dimethylphenol; 6-t-Butyl-2,4-xylenol; 6-tert-Butyl-2,4-dimethylphenol; Phenol, 2-(1,1-dimethylethyl)-4,6-dimethyl-; Prodox 340; Topanol A; 2,4-Xylenol, 6-tert-butyl-; [ChemIDplus] Antioxidant 30; 2,4-Dimethyl-6-tert-butylphenol; 6-(1,1-Dimethylethyl)-2,4-dimethylphenol; M 24; M 24 (antioxidant); 2-Methyl-6-tert-butyl-p-cresol; [CAMEO] 2,4-Xylenol, 6-t-butyl-; [OECD SIDS: 6-tert-Butyl-2,4-xylenol - 1996] UN2922

Category

Phenols

Description

Melting point = 22.3 deg C; [ChemIDplus] Yellow liquid with a phenolic odor; [CAMEO] Liquid; mp = 22-23 deg C; [Sigma-Aldrich MSDS]

Sources/Uses

Used as an antioxidant and rubber processing agent; [OECD SIDS: 6-tert-Butyl-2,4-xylenol - 1996] Used as an intermediate and in the formulation of lubricant additives, lubricants, greases, hydraulic fluids, and metalworking fluids; [ECHA REACH Registrations]

Comments

A repeated-dose/reproductive/developmental oral study of rats produced increased liver and kidney weights in parental animals (corresponding histopathological changes), loss of litters during lactation, a NOEL of 6 mg/kg/day for repeated-dose toxicity, and a NOEL of 30 mg/kg/day for reproductive toxicity; [OECD SIDS: 6-tert-Butyl-2,4-xylenol - 1996] Causes convulsions, acute pulmonary edema, and other changes in lungs, thorax, or respiration in dermal and oral lethal-dose studies of guinea pigs; [RTECS] May cause severe burns; [CAMEO] A skin and strong eye irritant; Harmful by ingestion (targets liver and kidneys); Highly toxic by skin absorption; [ECHA REACH Registrations] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; Highly toxic by inhalation; Toxic by and skin absorption; [Sigma-Aldrich MSDS] See "Xylenol."

Biomedical References

0.013 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Corrosive liquid, toxic, n.o.s."

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Processes

Industrial Processes with risk of exposure:

• Metal Machining