2,6-Diaminopyridine

Synonyms

DAP; DAP (amine); 2,6-Pyridinediamine; Pyridine, 2,6-diamino-; Pyridine-2,6-diyldiamine; [ChemIDplus] Pyridine-2,6-diamine; [EC: SCCS - Opinion] 2,6-DAP; [NTP] UN2671

Category

Pyridines

Description

Slightly brown solid; [EC: SCCS - Opinion] Light brown, yellow, or off-white powder or flakes; [Alfa Aesar MSDS]

Sources/Uses

Used in oxidative hair dyes; [EC: SCCS - Opinion] Used as an intermediate for pharmaceuticals and polyamides, epoxy curing agent, and coupler in hair dyes; [NTP]

Comments

One report of occupational contact dermatitis in the pharmaceutical industry; [NTP] A strong sensitizer based on the mouse local lymph node assay (LLNA); Oral LD50 (rat) = 50-300 mg/kg; A 90-day oral study of rats demonstrated the erythrocytes, spleen, kidney, and liver as target organs of toxicity (most changes recovering after 4-week recovery period); Developmental toxicity (decreased fetal and placental weights and incomplete thoracic vertebrae ossification) but no teratogenicity observed in oral study of rats in the presence of maternal toxicity; [EC: SCCS - Opinion] An irritant; Toxic by ingestion; [Alfa Aesar MSDS]

Biomedical References

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Aminopyridines."

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Dressing Hair
• Plastic Composites Manufacturing