2-Methoxy-4-nitroaniline

Synonyms

2-Amino-1-methoxy-5-nitrobenzene; 2-Amino-5-nitroanisol [Czech]; 2-Amino-5-nitroanisole; 2-Methoxy-4-nitrobenzenamine; 4-Amino-3-methoxynitrobenzene; 4-Nitro-6-methoxyaniline; 4-Nitro-o-anisidine; Amarthol Fast Red B Base; Aniline, 2-methoxy-4-nitro-; Anisole, 2-amino-5-nitro-; Azoamine Pink O; Azoene Fast Red B Base; Brentamine Fast Red B Base; C.I. 37125; C.I. Azoic Diazo Component 5; Dainichi Fast Red B Base; Daito Red Base B; Devol Red E; Diabase Red B; Diazo Fast Red B; Fast Red 5NA Base; Fast Red B; Fast Red B Base; Fast Red Base B; Hiltonil Fast Red B Base; Kako Red B Base; Kayaku Red B Base; Mitsui Red B Base; Naphthanil Red B Base; Naphthoelan Red B Base; Naphtoelan Red B Base; p-Nitro-o-anisidine; PNOA; Red B Base; Red Base Ciba V; Red Base IRGA V; Red Base NB; Sanyo Fast Red B Base; Shinnippon Fast Red B Base; Showa Fast Red B Base; Symulon Red B Base; Benzenamine, 2-methoxy-4-nitro-; o-Anisidine, 4-nitro-; [ChemIDplus]

Category

Other Aromatics (Nitrogen)

Description

Deep yellow solid; [NTP] Powder; [Alfa Aesar MSDS]

Sources/Uses

Used mainly as an intermediate for Pigment Yellow 74 (azo dye); Also used to dye textiles, as a chromogenic agent in the printing industry, and may have minor applications in histological staining; [NTP] Used to make fine chemicals; [ECHA REACH Registrations]

Comments

Suspected of being able to induce methemoglobinemia; Of 14 dye-stuff employees with positive patch test reactions to dye-stuffs, only 1 showed sensitization to this compound; Not a skin or eye irritant in rabbits; No evidence of skin sensitization in guinea pig maximization test; No formation of methemoglobin or increased Heinz bodies detected in cats following oral administration; [NTP] A 28-day oral study of rats produced changes in hematology, increased absolute and relative liver and spleen weights, myocardial necrosis, extramedullary hematopoiesis in the spleen, and a NOEL of 30 mg/kg/day; [JECDB] An irritant; May induce methemoglobinemia; Harmful by inhalation; Toxic by ingestion and skin absorption; Suspected mutagen; [Alfa Aesar MSDS] See "p-Nitroaniline." See "5-Nitro-o-anisidine."

Biomedical References

MetHgb is secondary toxic effect

Processes

Industrial Processes with risk of exposure:

• Textiles (Printing, Dyeing, or Finishing)