5-Bromouracil
Agent Name
5-Bromouracil
CAS Number
51-20-7
Formula
C4-H3-Br-N2-O2
Major Category
Biological Agents
Synonyms
5-Bromo-2,4(1H,3H)-pyrimidinedione; 5-BrU; 5-BU; Bromouracil; 2,4(1H,3H)-Pyrimidinedione, 5-bromo-; Uracil, 5-bromo-; [ChemIDplus] 5-Bromo-2,4-dihydroxypyrimidine; 5-Bromo-2,4-pyrimidinedione; [CAMEO]
Category
Nucleic Acids and Derivatives
Description
Solid; [Merck Index] White to off-white powder; [Acros Organics MSDS]
Sources/Uses
Used as an experimental mutagen; Alters DNA base-pair sequences by replacing thymine; [Merck Index]
Comments
Causes somnolence, muscle weakness, and dyspnea in intraperitoneal lethal-dose studies of mice (LD50 = 1,400 mg/kg); [RTECS] May cause irritation; Harmful by ingestion; Risk of irreversible adverse health effects; [Acros Organics MSDS] See "Uracil."
Biomedical References
Exposure Assessment
Vapor Pressure
2.27E-07 mm Hg
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.