Halothane

Synonyms

(+-)-2-Bromo-2-chloro-1,1,1-trifluoroethane; 1,1,1-Trifluoro-2-bromo-2-chloroethane; 1,1,1-Trifluoro-2-chloro-2-bromoethane; 1-Bromo-1-chloro-2,2,2-trifluoroethane; 2,2,2-Trifluoro-1-chloro-1-bromoethane; 2-Brom-2-chlor-1,1,1-trifluorethan; 2-Bromo-2-chloro-1,1,1-trifluoroethane; Alotano; Alotano [DCIT]; Anestan; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; Chalothane; Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-; Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-, (+-)-; Fluktan; Fluorotane; Fluothane; Freon 123B1; Ftorotan; Ftorotan [Russian]; Ftuorotan; Halan; Halotan; Halotano; Halotano [INN-Spanish]; Halothan; Halothane; Halothanum [INN-Latin]; Halsan; Narcotan; Narcotane; Narcotann NE-spofa [Russian]; Narkotan; Phthorothanum; Rhodialothan; [ChemIDplus] UN8027

Category

Waste Anesthetic Gases

Description

Clear, colorless liquid with a sweetish, pleasant odor; inhalation anesthetic; [NIOSH]

Sources/Uses

Used as an anesthetic; [HSDB]

Comments

See "WASTE ANESTHETIC GASES" Halothane is in the list of "Some volatile substances which may be abused by inhalation" published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1] Inhalation of high concentrations can cause CNS depression, cardiac arrhythmias, and liver injury; [ICSC] TLV Basis is developmental effects, liver damage, and CNS impairment; [ACGIH]

Reference Link #1

Biomedical References

Insufficient data

5 ppm

5 ppm

302 mm Hg

LC50 (rat) = 29,000 ppm

Explanatory Notes

NIOSH Rel = 60 min. ceiling of 2 ppm;

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect