Acetophenone

Synonyms

1-Phenyl-1-ethanone; 1-Phenylethanone; Acetofenon [Czech]; Acetophenon; Acetylbenzene; Acetylbenzol; Benzene, acetyl-; Benzoyl methide; Benzoylmethide; Ethanone, 1-phenyl-; Hypnone; Ketone, methyl phenyl; Methyl phenyl ketone; Phenyl methyl ketone; USAF EK-496; [ChemIDplus] UN 1993

Category

Aromatic Ketones

Description

Liquid that forms crystals at low temperature; [Merck Index]

Sources/Uses

Used in textile coatings; [Olson, p. 661] Used in perfumes for orange blossom odor; Also used in organic synthesis and as a polymerization catalyst for olefins; [Merck Index] Used in the past as an analgesic and anesthetic; [ACGIH] Used as a solvent in plastics and resins and a flavoring agent in foods; [HSDB]

Comments

A skin and eye irritant; Can cause CNS depression at high concentrations; [Olson, p. 661] Inhalation of high concentration can cause unconsciousness; [ICSC] In rats, the lethal concentration is >210 ppm for 8 hours; In mice, the lethal concentration (LC50) is 1200 mg/m3/4H (244 ppm/4H); [RTECS] TLV Basis: Irritation, CNS impairment; Pregnancy loss; [ACGIH]

Biomedical References

Insufficient data

10 ppm

0.397 mm Hg

0.17 ppm

Odor Threshold High

0.6 ppm

100 ppm

LC (rat) = >210 ppm/8h

Explanatory Notes

Odor Threshold avg = 0.5 ppm. [CHEMINFO] mp = 20.5 deg C; bp = 202 deg C; Flash point = 105 deg C; [Merck Index] VP from ChemIDplus;

10 ppm

Acute solvent syndrome

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Plastic Composites Manufacturing
• Textiles (Printing, Dyeing, or Finishing)