Piperazine and salts

Synonyms

1,4-Diazacyclohexane; 1,4-Diethylenediamine; 1,4-Piperazine; Antiren; Asca-Trol No. 3; Diethylenediamine; Diethyleneimine; Dispermine; Entacyl; Eraverm; Eraverm (VAN); Hexahydro-1,4-diazine; Hexahydropyrazine; Lumbrical; Piperazidine; Piperazin [German]; Piperazine; Piperazine, anhydrous; Pipersol; Pyrazine hexahydride; Pyrazine, hexahydro-; Uvilon; Vermex; Worm-A-Ton; Wurmirazin; [ChemIDplus] Piperazine salts include dihydrochloride, hexahydrate, citrate, phosphate, propionate, adipate, tartrate, quinate, and sebacate; [ACGIH] UN2579

Category

Piperazines

Description

Colorless solid, hygroscopic, with a pungent odor; [ICSC]

Sources/Uses

Piperazine salts are used as anthelmintic drugs; Also used to make corrosion inhibitors, insecticides, curing agents for polychloroprene, and antihistamines; [HSDB] Used to make fibers, drugs, and insecticides; Also used in veterinary medicine to eradicate pinworms; [ACGIH]

Comments

Corrosive to skin; [Quick CPC] A corrosive substance that can cause pulmonary edema; May cause skin sensitization and asthma after prolonged contact; May cause CNS injury if ingested in large amounts; [ICSC] Salts include dihydrochloride, hexahydrate, citrate, phosphate, propionate, adipate, tartrate, quinate, and sebacate. TLV Basis = respiratory sensitization and asthma; A 1% to 5% solution caused necrosis of the rabbit cornea; Not genotoxic or mutagenic; No teratogenic effects at doses not maternally toxic; Causes tremors and ataxia at doses >45 mg/kg in dogs and cats; NOAEL = 25 mg/kg/day for liver toxicity in dogs; [ACGIH] Causes burns; Inhalation of high concentrations may produce acute pneumonitis and pulmonary edema; [MSDSonline] See "Piperazine dihydrochloride."

Biomedical References

No

0.03 ppm, inhalable fraction and vapor, measured as piperazine

0.16 mm Hg

LC50 (mice) = 5,400 mg/m3/2h

Explanatory Notes

Flash point = 81 deg C; [CHEMINFO] VP from ChemIDplus;

high ambient temp required

Yes

Yes

Yes

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Contact dermatitis, allergic