Phosdrin

Agent Name
Phosdrin
Alternative Name
Mevinphos
CAS Number
7786-34-7
Formula
C7-H13-O6-P
Major Category
Pesticides
Phosdrin formula graphical representation
Synonyms
(2-Methoxycarbonyl-1-methyl-vinyl)-dimethyl-fosfaat [Dutch]; (2-Methoxycarbonyl-1-methyl-vinyl)-dimethyl-phosphat [German]; (2-Metossicarbonil-1-metil-vinil)-dimetil-fosfato [Italian]; 1-Methoxycarbonyl-1-propen-2-yl dimethyl phosphate; 2-Butenoic acid, 3-((dimethoxyphosphinyl)oxy)-, methyl ester; 2-Carbomethoxy-1-methylvinyl dimethyl phosphate; 2-Carbomethoxy-1-propen-2-yl dimethyl phosphate; 2-Methoxycarbonyl-1-methylvinyl dimethyl phosphate; 3-((Dimethoxyphosphinyl)oxy)-2-butenoic acid methyl ester; 3-Hydroxycrotonic acid methyl ester dimethyl phosphate; CMDP; Compound 2046; Crotonic acid, 3-hydroxy-, methyl ester, dimethyl phosphate; Dimethyl (1-methoxycarboxypropen-2-yl)phosphate; Dimethyl 2-methoxycarbonyl-1-methylvinyl phosphate; Dimethyl methoxycarbonylpropenyl phosphate; Dimethyl phosphate of methyl 3-hydroxy-cis-crotonate; Dimethyl-1-carbomethoxy-1-propen-2-yl phosphate; Duraphos; Fosdrin; Gesfid; Meniphos; Menite; Methyl 3-((dimethoxyphosphinyl)oxy)-2-butenoate (9CI); Methyl 3-(dimethoxyphosphinoyloxy)but-2-enoate; Methyl 3-(dimethoxyphosphinyloxy)crotonate; Methyl 3-hydroxy-alpha-crotonate dimethyl phosphate; Methyl 3-hydroxycrotonate dimethyl phosphate ester (8CI); Methyl-3-hydroxy-alpha-crotonate, dimethyl phosphate ester; Mevinfos [Dutch]; Mevinphos; O,O-Dimethyl 1-carbomethoxy-1-propen-2-yl phosphate; O,O-Dimethyl O-(1-methyl-2-carboxyvinyl) phosphate; O,O-Dimethyl-O-(2-carbomethoxy-1-methylvinyl) phosphate; O,O-Dimethyl-O-2-methoxycarbonyl-1-methyl-vinyl-phosphat [German]; OS 2046; PD 5; PD 5 (pesticide); Phosfene; Phosphate de dimethyle et de 2-methoxycarbonyl-1 methylvinyle [French]; Phosphoric acid, (1-methoxycarboxypropen-2-yl) dimethyl ester; Phosphoric acid, dimethyl ester, ester with methyl 3-hydroxycrotonate; [ChemIDplus]
Category
Organophosphate Insecticides
Description
Pale-yellow to orange liquid with a weak odor; [NIOSH]
Sources/Uses
Used to kill insects on vegetables, alfalfa, fruits, and nuts; [HSDB]
Comments
It is applied 1-10 days before harvest; it dissipates quickly. [HSDB] Skin sensitization occurs rarely. [Kanerva, p. 1817] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]
Reference Link #1
Biomedical References

Exposure Assessment

BEI
Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
0.01 mg/m3, inhalable fraction and vapor
PEL (OSHA)
0.1 mg/m3
MAK
0.093 mg/m3
IDLH (NIOSH)
36 mg/m3
Vapor Pressure
0.003 mm Hg
Lethal Concentration
LC50 (rat) = 14 ppm/1h

Adverse Effects

Skin Sensitizer
Yes
ACGIH Carcinogen
Not Classifiable
Other Poison
Organophosphate

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: