18-Crown-6
Agent Name
18-Crown-6
CAS Number
17455-13-9
Formula
C12-H24-O6
Major Category
Other Classes
Synonyms
1,4,7,10,13,16-Hexanoxacyclooctadecane; 1,4,7,10,13,16-Hexaoxacyclooctadecane; 18-Crown-6; Ethylene oxide cyclic hexamer; [ChemIDplus]
Category
Other Organic Compounds
Description
Clear, odorless, hygroscopic liquid soluble in water and most organic solvents; [Ullmann] White crystals; [MSDSonline]
Sources/Uses
Drug/ Therapeutic Agent; [ChemIDplus] Used as complexing agents with ammonium ions and metal ions (alkali and alkaline-earth metals); Used as catalysts to make organic chemicals; [Ullmann]
Comments
If absorbed, can cause electrolyte imbalance affecting the CNS; Signs of intoxication include hyperventilation, tremor, incoordination, and CNS depression; May damage the skin and eyes; LD50 (mouse) by ingestion is 0.7 g/kg; LD50 (rabbit) by skin absorption is 200 mg/kg; [Ullmann] Toxic by ingestion; A skin, eye, and respiratory tract irritant; Oral LD50 (rat) = 525 mg/kg; Dermal LDLo (rat) = 7000 mg/kg; High-dose feeding causes seizures, weight loss, and liver injury in experimental animals; [MSDSonline]
Biomedical References
Exposure Assessment
Vapor Pressure
6.67E-05 mm Hg
Explanatory Notes
mp = -38 deg C; bp = 116 deg C; [Ullmann] mp = 39-40 deg C; [MSDSonline]
NFPA
must be preheated
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.