Diazinon

Synonyms

4-Pyrimidinol, 2-isopropyl-6-methyl-, O-ester with O,O-diethyl phosphorothioate; AG-500; Alfa-tox; Antigal; Bassadinon; Basudin; Basudin 10 G; Basudin S; Bazuden; Ciazinon; Compass; Compass (insecticide); Cooper's Flystrike Powder; Dacutox; Dassitox; Dazzel; Delzinon; Diazajet; Diazide; Diazinon ag 500; Diazinone; Diazitol; Diazol; Dicid; Diethyl 2-isopropyl-4-methyl-6-pyrimidinyl phosphorothionate; Diethyl 4-(2-isopropyl-6-methylpyrimidinyl)phosphorothionate; Dimpilato [INN-Spanish]; Dimpylat; Dimpylate; Dimpylatum [INN-Latin]; Disonex; Dizictol; Dizinil; Dizinon; Drawizon; Dyzol; Ektoband; Exodin; Flytrol; G 24480; G 301; G-24480; Galesan; Garden Tox; Geigy 24480; Isopropylmethylpyrimidyl diethyl thiophosphate; KFM Blowfly Dressing; Kayazinon; Kayazol; Kleen-Dok; Knox Out 2FM; Knox Out Yellow Jacket Contorl; Knox-out; Meodinon; Nedcidol; Neocidol; Neocidol (oil); Neodinon; Nipsan; Nucidol; O,O-Diaethyl-O-(2-isopropyl-4-methyl)-6-pyrimidyl-thionophosphat [German]; O,O-Diaethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiophosphat [German]; O,O-Diethyl 2-isopropyl-4-methylpyrimidyl-6-thiophosphate; O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate; O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate; O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl)phosphorothioate; O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl)phosphorothioate; O,O-Diethyl O-6-methyl-2-isopropyl-4-pyrimidinyl phosphorothioate; O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)-phosphorothioate; O,O-Diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl)phosphorothioate; O,O-Diethyl-O-(2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat [Dutch]; O,O-Dietil-O-(2-isopropil-4-metil-pirimidin-6-il)-monotiofosfato [Italian]; O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate; OMS 469; Oleodiazinon; Optimizer; PT 265; Phosphorothioate, O,O-diethyl O-6-(2-isopropyl-4-methylpyrimidyl); Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester; Phosphorothioic acid, O,O-diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) ester; Phosphorothioic acid, O,O-diethyl O-(isopropylmethylpyrimidinyl) ester; Sarolex; Spectracide; Srolex; Terminator; Thiophosphate de O,O-diethyle et de O-2-isopropyl-4-methyl-6-pyrimidyle [French]; Thiophosphoric acid 2-isopropyl-4-methyl-6-pyrimidyl diethyl ester; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Colorless liquid with a faint ester-like odor. [insecticide]; [NIOSH]

Sources/Uses

Exterminators use a 85-90% concentration, while the liquid or granules used for house and garden contains 1-5% diazinon. [ATSDR ToxFAQs]

Comments

In animals, diazinon has a half-life of about 12 hours. Cows completely eliminate diazinon within two weeks of the last exposure. [http://ace.orst.edu/info/nptn] Classified as mildly or moderately toxic depending upon the formulation; [EXTOXNET] Diazinon causes hepatic steatosis in high-dose feeding studies of rats. [Zimmerman, p. 394] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Use on sod farms and golf courses cancelled by EPA in 1988; [EXTOXNET]

Reference Link #1

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Yes

0.01 mg/m3, inhalable fraction and vapor

0.1 mg/m3, inhalable fraction

0.0001 mm Hg

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Probable (2a)

Not Classifiable

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)