Dioxathion

Synonyms

Delnav; 1,4-Diossan-2,3-diil-bis(O,O-dietil-ditiofosfato) [Italian]; 1,4-Diossan-2,3-diyl-bis(O,O-dietil-ditiofosfato) [Italian]; 1,4-Dioxaan-2,3-diyl-bis(O,O-diethyl-dithiofosfaat) [Dutch]; 1,4-Dioxan-2,3-diyl O,O,O',O'-tetraethyl di(phosphorodithioate); 1,4-Dioxan-2,3-diyl S,S-di(O,O-diethyl phosphorodithioate); 1,4-Dioxan-2,3-diyl bis(O,O-diethyl phosphorothiolothionate); 1,4-Dioxan-2,3-diyl bis(O,O-diethylphosphorothiolothionate); 1,4-Dioxan-2,3-diyl-bis(O,O-diaethyl-dithiophosphat) [German]; 2,3-Bis(diethoxyphosphinothioylthio)-1,4-dioxane; 2,3-P-Dioxan-S,S'-bis(O,O-diaethyldithiophosphat) [German]; 2,3-p-Dioxandithiol S,S-bis(O,O-diethyl phosphorodithioate); 2,3-p-Dioxanedithiol S,S-bis(O,O-diethyl phosphorodithioate); AC 528; Bis(dithiophosphate de O,O-diethyle) de S,S'-(1,4-dioxanne-2,3-diyle) [French]; Co-Nav; Delanov; Delnatex; Delnav; Deltic; Dioxane phosphate; Dioxathion; Dioxation; Dioxationum [INN-Latin]; Hercules 528; Hercules AC528; Kavadel; Navadel; Ruphos; S,S'-(1,4-Dioxane-2,3-diyl) O,O,O',O'-tetraethyl bis(phosphorodithioate); S,S'-(1,4-Dioxane-2,3-diyl) O,O,O',O'-tetraethyl di(phosphorodithioate); S,S'-1,4-Dioxane-2,3-diyl bis(O,O-diethyl phosphorodithioate) (9CI); S,S'-p-Dioxane-2,3-diyl bis(O,O-diethyl phosphorodithioate) (8CI); p-Dioxane-2,3-dithiol, S,S-diester with O,O-diethyl phosphorodithioate; p-Dioxane-2,3-diyl ethyl phosphorodithioate; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Viscous, brown, tan, or dark-amber liquid. [insecticide] [Note: Technical product is a mixture of cis- & trans-isomers.]; [NIOSH]

Sources/Uses

Insecticide; acaricide; [HSDB]

Comments

Inhalation of high concentrations may cause CNS effects; Cholinesterase inhibitor; [ICSC] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Registration was cancelled in 1994. [HSDB]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Yes

0.1 mg/m3, inhalable fraction and vapor

8.76E-08 mm Hg

LC50 (rat) = 1,398 mg/m3/1h

Not Classifiable

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning