1,2,3,5-Tetrachlorobenzene
Agent Name
1,2,3,5-Tetrachlorobenzene
CAS Number
634-90-2; 63697-21-2
Formula
C6-H2-Cl4
Major Category
Other Classes
Synonyms
Benzene, 1,2,3,5-tetrachloro-; [ChemIDplus] 1,2,3,5-Benzene tetrachloride; 1,2,4,6-Tetrachlorobenzene; [CAMEO]
Category
Halogenated Monoaromatics
Description
Colorless solid; [HSDB] White or off-white solid; [CAMEO]
Sources/Uses
Used as an intermediate for herbicides and defoliants; as an insecticide; as an impregnant for moisture resistance; for electrical insulation; for temporary protection in packing; Not commercially produced in the US; [HSDB] Used for electrical insulating fluids in transformers; A break-down product of the pesticide Lindane; [CHEMINFO]
Comments
A decrease in the number of fetuses was the only significant effect observed at the highest dose level (200 mg/kg) in a study with pregnant rats (no teratogenic effects or histopathological changes in mothers or fetuses); Caused histological changes to liver and kidney in 13 week feeding study with rats; Effects in two month feeding study include altered liver function, prothrombin index, blood cholesterol, and adrenal hypertrophy; [HSDB] May cause irritation to skin, eyes, nose, throat, and respiratory tract; Long term exposure may cause kidney and liver injury; [CHEMINFO] Effects to the liver in short term gavage studies with rats include porphyria, enlargement, and focal necrosis; Histopathological changes observed to kidney and liver in 90 day feeding study with rats; [INCHEM]
Biomedical References
Exposure Assessment
Vapor Pressure
0.073 mm Hg
Explanatory Notes
Flash point > 113 deg C; [CAMEO]
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: