1,2-Diaminocyclohexane

Synonyms

1,2-Cylohexanediamine; Cyclohex-1,2-ylenediamine; [ChemIDplus] UN2735

Category

Amines, Aromatic

Description

Dark liquid with an amine odor; [CAMEO]

Sources/Uses

Used to make bicyclic pyrazine derivatives; [HSDB]

Comments

A corrosive substance; [CAMEO] Effects during recovery period from a 4-hour, lethal-concentration study of rats include skin lesions, discharge from the nose, and labored breathing; Lesions of the nasal mucosa observed in 2-week inhalation study with rats; No other gross or histopathological changes observed; Considered a severe skin and moderate eye irritant based on studies with rabbits; Not sensitizing to skin of guinea pigs; Dermal LD50 (test substance 69.5% 1,6-Hexanediamine and 30.5% 1,2-Diaminocyclohexane) = 7500 mg/kg in albino rabbits and produced severe irritation with necrosis; [EPA HPVIS] Observations in 28-day feeding with rats at highest tested dose (500 mg/kg) include pale discoloration of liver and increased liver enzymes; Decrease in litter size and increased postnatal loss at highest dose; Caused skin sensitization in guinea pigs (20/20 at 24 hours and 13/20 at 48 hours) [ToxPlanet: TSCATS] Causes burns; Potential skin sensitizer; May cause acute pneumonitis after inhalation; [Alfa Aesar MSDS]

Reference Link #1

Biomedical References

0.407 mm Hg

LCLo (rat) = 3,200 mg/m3/4h

Explanatory Notes

Flash point > 93 deg C; [CAMEO] The Guide in the Emergency Response Guidebook is for "Amines, liquid, corrosive, n.o.s." VP from ChemIDplus;

Yes

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic