1,2-Dihydro-2,2,4-trimethylquinoline
Agent Name
1,2-Dihydro-2,2,4-trimethylquinoline
CAS Number
147-47-7
Formula
C12-H15-N
Major Category
Nitrogen Compounds
Synonyms
2,2,4-Trimethyl-1,2-dihydrochinolin [Czech]; 2,2,4-Trimethyl-1,2-dihydroquinoline; Acetone anil; Acetone anil (quinoline deriv.); Acetone anil (quinoline derivative); Agerite resin D; Flectol A; Flectol H; Flectol pastilles; Polnox R; Quinoline, 1,2-dihydro-2,2,4-trimethyl-; Trimethyl dihydroquinoline; Trimethyl-1,2-dihydroquinoline; Vulkanox HS/LG; Vulkanox HS/powder; [ChemIDplus]
Category
Quinolines
Description
Light tan powder; mp = 120 deg C; [HSDB] Dark cloudy copper-colored or yellow liquid; mp = 26-27 deg C; [CAMEO] Amber or brown granules; mp = 80-100 deg C; [Redox MSDS]
Sources/Uses
Used as a monomer; The polymer is a rubber antioxidant; [HSDB]
Comments
Weight loss, decreased hemoglobin, CNS depression, and abnormal liver function observed in rats dosed long-term by intragastric tube; [HSDB] No evidence of carcinogenicity in mice or female rats and some evidence of carcinogenicity in male rats in 2-year dermal studies; [NTP] Causes thymus and liver changes and weight loss in 13-week intermittent dermal study of rats; Causes changes in urine and serum composition and weight loss in 21-week intermittent inhalation study of rats; Causes impaired liver function in 30-day intermittent oral study of rats; [RTECS] May cause skin sensitization, eye irritation, and respiratory tract irritation; [Redox MSDS] Search for 147-47-7 AND (sensitizer OR sensitization OR allergic): no results; [PubMed]
Biomedical References
Exposure Assessment
Explanatory Notes
Flash point = 101 deg C; [CAMEO]
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.