1,4-Epoxy-p-menthane

Synonyms

1,4-Cineol; 1,4-Cineole; 1,4-Cineole (natural); 1-Isopropyl-4-methyl-7-oxabicyclo(2.2.1)heptane; 1-Methyl-4-(1-methylethyl)-7-oxabicyclo(2.2.1)heptane; 7-Oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl- (6CI); 7-Oxabicyclo(2.2.1)heptane, 1-methyl-4-(1-methylethyl)-; Isocineole; p-Cineole; p-Menthane, 1,4-epoxy-; [ChemIDplus] UN1993

Category

Other Organic Compounds

Description

Colorless liquid with a minty lime odor; [HSDB]

Sources/Uses

Used as a flavoring and fragrance agent; Naturally occurring in some essential oils; [HSDB]

Comments

Safe when used as a flavoring agent in food; [JECFA] 1,8-Cineole (eucalyptol) is toxic by ingestion; As little as 1 mL can cause coma and 3.5 mL can cause death; Patients may have epigastric burning, nausea, ataxia, muscle weakness, delirium, stupor, and occasionally convulsions; Recovery reported after a dose as high as 30 mL; In a series of 109 children, eucalyptus oil ingestion caused only minor CNS depression when dose was 2-3 mL; [HSDB] May cause irritation; [MSDSonline]

Biomedical References

1.93 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Flammable liquid, n.o.s." VP from ChemIDplus;

Acute solvent syndrome

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect