N-Nitrosodimethylamine
Agent Name
N-Nitrosodimethylamine
Alternative Name
N,N-Dimethylnitrosoamine
CAS Number
62-75-9
Formula
C2-H6-N2-O
Major Category
Nitrogen Compounds
Synonyms
N,N-Dimethylnitrosoamine; DMN; DMNA; Dimethylamine, N-nitroso-; Dimethylnitrosamin [German]; Dimethylnitrosamine; Dimethylnitrosoamine; Methanamine, N-methyl-N-nitroso-; N,N-Dimethylnitrosamine; N-Dimethyl-nitrosamine; N-Methyl-N-nitrosomethanamine; N-Nitroaodimethylamine; N-Nitroso-N,N-dimethylamine; N-Nitrosodimethylamine; NDMA; Nitrosamine, dimethyl-; Nitrosodimethylamine; [ChemIDplus] UN2810
Category
Nitrosamines
Description
Yellow, oily liquid with a faint, characteristic odor; [NIOSH]
Sources/Uses
Used as an intermediate in the production of 1,1-dimethylhydrazine; DMNA contaminates common organic amines and may occur as a byproduct of industrial processes; [ACGIH]
Comments
A animal carcinogen; At least one death and a number of cases of hepatic injury have been reported in workers handling DMNA. [ACGIH] A skin, eye, and respiratory tract irritant; May cause liver injury and jaundice; [ICSC]
Restricted
Regulated as a carcinogen: See 29CFR1910.1003 (Code of Federal Regulation).
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Yes
Vapor Pressure
2.7 mm Hg
Odor Threshold Low
0.0079 ppm
Odor Threshold High
0.01 ppm
Lethal Concentration
LC50 (rat) = 78 ppm/4h
Explanatory Notes
Carcinogen--No TLV; Odor threshold from AIHA; Flash point = 142 deg F; VP from HSDB;
Half Life
No reports found; [TDR, p. 955]
Reference Link #2
Adverse Effects
Hepatotoxin
Occupational hepatotoxin (principal effect)
IARC Carcinogen
Probable (2a)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Confirmed Animal
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: