1-Chloro-2,6-dinitrobenzene

Synonyms

1,3-Dinitro-2-chlorobenzene; 2,6-Dinitrochlorobenzene; 2-Chloro-1,3-dintrobenzene; Benzene, 2-chloro-1,3-dinitro-; [ChemIDplus] UN1577

Category

Nitros, Aromatic

Description

Yellow solid; [Merck Index] Yellow crystals; [MSDSonline]

Sources/Uses

Used as an intermediate in the manufacture of picric acid; Has been used as a topical adjuvant in immunotherapy of tumors; [HSDB]

Comments

Emergency treatment: "Nitrobenzene." [HSDB] May cause primary and allergic dermatitis; A skin irritant; [Merck Index] Dinitrochlorobenzene (DNCB) is a potent contact allergen that has been used in the treatment of alopecia areata and cutaneous metastasis of malignant melanoma; [Kanerva, p. 1787] An irritant; [MSDSonline] See "1-Chloro-2,4-dinitrobenzene."

Biomedical References

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic