1-Chloro-2-methyl-1-propene

Synonyms

1-Chloro-2-methylpropene; 1-Chloro-2-methylpropene (IUPAC); 1-Chloroisobutylene; 1-Propene, 1-chloro-2-methyl-; 2,2-Dimethylvinyl chloride; 2-Methyl-1-chloropropene; 2-Methyl-1-propenyl chloride; Dimethylvinylchloride; Isocrotyl chloride; Propene, 1-chloro-2-methyl-; alpha-Chloroisobutylene; beta, beta-Dimethylvinyl chloride; beta,beta-Dimethylvinyl chloride; [ChemIDplus] UN1993

Category

Halogenated Aliphatics, Unsaturated

Description

Colorless, highly volatile liquid; [HSDB] Dark yellow to pale orange liquid; [CAMEO] Very faintly yellow-brown liquid; [MSDSonline]

Sources/Uses

Used in organic synthesis and as a research chemical; [Merck Index] Not commercially produced in the US; [HSDB] Impurity in the manufacture of 3-chloro-2-methylpropene; No known commercial use; [IARC]

Comments

An eye and respiratory tract irritant; Possesses anesthetic characteristics; Squamous cell carcinomas have been observed in feeding studies with rats; No evidence of mutagenicity in various strains of Salmonella typhimurium; Emergency medical treatment: see "Propylene dichloride." [HSDB] A skin, eye, and respiratory tract irritant; May cause liver and kidney injury and CNS effects (anesthesia); [CAMEO] Rapidly excreted by expiration and in urine; Effects in high-dose studies with rats include tissue necrosis in various organs (including small and large intestine, thymus, and spleen) and proliferation of forestomach cells; Observations of mutagenicity in single studies with cultured rodent cells (gene mutation and sister chromatid exchange, but no chromosomal aberrations) and insects (gene and chromosomal mutation); Mutagenic to bacteria; “Sufficient evidence” for carcinogenicity in laboratory animals; [IARC]

Biomedical References

212 mm Hg

LC50 (rat) = 400 mg/m3/4h

Explanatory Notes

Flash point = -1 deg C; [CAMEO] The Guide in the Emergency Response Guidebook is for "Flammable liquid, n.o.s." VP from ChemIDplus;

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Anticipated human carcinogen

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect