1,3-Benzenediamine, 2-methyl-; 2,6-Diamino-1-methylbenzene; 2,6-Toluylenediamine; 2,6-Tolylenediamine; 2-Methyl-1,3-benzenediamine; 2-Methyl-1,3-phenylenediamine; 2-Methyl-m-phenylenediamine; Toluene, 2,6-diamino-; Toluene-2,6-diamine; o-Toluene diamine; [ChemIDplus]
Colorless solid; Turns brown when exposed to air; [ICSC] White to brown solid; [MSDSonline]
Used as a chemical intermediate for toluene diisocyanate; in the production of polyurethane foam, elastomers, polyether polyols, dyes, and rubber chemicals; as a curing agent for epoxy resins; and as a monomer, chain extender, and crosslinker for polymers; [HSDB] Commercially available as 80:20 mixture of the meta (2,4 and 2,6) isomers; The commercial mixture may be represented by CAS #'s 25376-45-8 and 26966-75-6 (although these CAS #’s may also be used for other isomeric mixtures); [OECD SIDS] Meta-DAT (80:20 or 65:35 mixture of 2,4 and 2,6 isomers): Used to make urethane products, dyes, corrosion inhibitors, and rubber antioxidants; [INCHEM]
Exhibits the same genotoxic behavior in the Ames Salmonella assay as the 2,4 isomer, and both compounds are mutagenic with metabolic activation; Unlike the 2,4 isomer, which is a strong hepatocarcinogen, the 2,6 isomer produced no increase in tumor frequency in rodent bioassays; Emergency treatment: Methemoglobinemia; [HSDB] A skin, eye, and respiratory tract irritant; Can induce methemoglobinemia; May cause skin sensitization; Can be absorbed through skin; [ICSC] May cause skin sensitization; [eChemPortal: ESIS] Mutagenic; [RTECS] See "2,4-Diaminotoluene."
MetHgb is secondary toxic effect
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Occupational diseases associated with exposure to this agent:
Industrial Processes with risk of exposure: