2-Chloro-1-propanol
Agent Name
2-Chloro-1-propanol
Alternative Name
Propylene chlorohydrin
CAS Number
78-89-7
Formula
C3-H7-Cl-O
Major Category
Other Classes
Synonyms
Propylene chlorohydrin; 1-Hydroxy-2-chloropropane; 1-Propanol, 2-chloro-; 2-Chloropropanol; 2-Chloropropyl alcohol; Propylenechlorohydrin; beta-Chloropropyl alcohol; [ChemIDplus]
Category
Halogenated Alcohols
Description
Colorless liquid with a pleasant odor; [Merck Index]
Sources/Uses
Used in organic synthesis; [Hawley] Used to make propylene oxide; [HSDB] Produced as residue on foods when fumigated with propylene oxide; [WHO] A constituent of technical grade 1-chloro-2-propanol at 25%; [ACGIH]
Comments
External application to rabbit eyes scored 8 on a scale of 1-10 (10 being most severe) for degree of injury after 24 hours; Rats exposed 15 times to six hours of inhalation at 250 ppm displayed lung congestion and perivascular edema; Decreased body weights and histopathology in the acinar cells of the pancreas were the only observations in high-dose animal feeding studies; [HSDB] General anesthetic effect in lethal-dose feeding studies of guinea pigs; [RTECS] A skin and severe eye irritant; May cause hemolysis; [CAMEO] See "1-Chloro-2-propanol."
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
1 ppm
Vapor Pressure
5.25 mm Hg
Lethal Concentration
LCLo (rat) > 500 ppm/4h
Explanatory Notes
Flash point = 51.6 deg C; [Hawley] VP from ChemIDplus;
NFPA
high ambient temp required
Adverse Effects
Neurotoxin
Acute solvent syndrome
ACGIH Carcinogen
Not Classifiable
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: