3,4-Dichloroaniline

Synonyms

1-Amino-3,4-dichlorobenzene; 3,4-DCA; 3,4-Dichloranilin; 3,4-Dichloraniline; 3,4-Dichlorobenzenamine; 3,4-Dichlorophenylamine; 4,5-Dichloroaniline; 4-Amino-1,2-dichlorobenzene; Aniline, 3,4-dichloro-; Benzenamine, 3,4-dichloro-; DCA; DCA (VAN); LY 004892; m.p-Dichloroaniline; [ChemIDplus] UN1590; UN3442

Category

Amines, Aromatic

Description

Light-brown solid; [ICSC] Darkens on exposure to light and air; [CHEMINFO] Light brown crystalline solid; [MSDSonline]

Sources/Uses

Used to make dyes and pesticides; [Hawley]

Comments

An eye irritant; Can induce methemoglobinemia; May cause skin sensitization; [ICSC] High exposures can cause liver and kidney injury; May be toxic after skin absorption; [CAMEO] Toxic by inhalation, ingestion, and skin absorption; May cause serious damage to eyes; [eChemPortal: ESIS] No liver injury detected in study of workers exposed to 3,4-dichloroaniline in the production of diuron; Oral LD50 (rats) = 648 mg/kg; Dermal LD50 (cats) = 700 mg/kg; [HSDB] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; May cause skin sensitization; Can be absorbed through skin; Effects in high-dose animal studies include convulsions, cyanosis, lacrimation, and methemoglobinemia; [MSDSonline] Danger of cutaneous absorption; Danger of skin sensitization; [MAK]

Biomedical References

0.00632 mm Hg

LCLo (rat) = 65 mg/m3/4h

Explanatory Notes

Flash point = 166 deg C; [ICSC] The Guide in the Emergency Response Guidebook is for "Dichloroanilines, solid."

must be preheated

Yes

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic