3,4-Dichloronitrobenzene
Agent Name
3,4-Dichloronitrobenzene
CAS Number
99-54-7
Formula
C6-H3-Cl2-N-O2
Major Category
Nitrogen Compounds
Synonyms
1,2-Dichloro-4-nitrobenzene; 1-Nitro-3,4-dichlorobenzene; 3,4-Dichlornitrobenzen [Czech]; 3,4-Dichloronitrobenzen [Czech]; AI3-03268 (USDA); Benzene, 1,2-dichloro-4-nitro-; DCNB; [ChemIDplus] UN1578
Category
Nitros, Aromatic
Description
Colorless to tan solid; [ICSC] Fine yellow crystals; [MSDSonline]
Sources/Uses
Used to make herbicides, insecticides, and dyes; [HSDB]
Comments
A skin and eye irritant; May cause effects on the blood; [ICSC] May cause liver damage; [CAMEO] Causes methemoglobinemia in high-dose animals experiments; Methemoglobinemia also reported in exposed workers; Dermal LD50 (rats) >2000 mg/kg; Oral LDLo (rabbits) = 950 mg/kg; [HSDB] An eye irritant; Can be absorbed through skin; May cause skin sensitization; May induce methemoglobinemia; Effects in high-dose animal studies include cyanosis; [MSDSonline] No evidence of skin sensitization; [INCHEM: SIDS] Danger of cutaneous absorption; Could be carcinogenic for man but not conclusive because of insufficient data; [MAK]
Biomedical References
Exposure Assessment
Vapor Pressure
0.014 mm Hg
Lethal Concentration
LC50 (rat) = 10,000 mg/m3/4h
Explanatory Notes
Flash point = 124 deg C; [ICSC] The Guide in the Emergency Response Guidebook is for "Chloronitrobenzenes, solid."
WEEL
1 ppm
Adverse Effects
Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.