4-Chloroaniline

Synonyms

1-Amino-4-chlorobenzene; 4-Amino-1-chlorobenzene; 4-Aminochlorobenzene; 4-Chloranilin [Czech]; 4-Chloro-1-aminobenzene; 4-Chlorobenzamine; 4-Chlorobenzenamine; 4-Chlorophenylamine; Aniline, 4-chloro-; Aniline, p-chloro-; Benzenamine, 4-chloro-; Benzeneamine, 4-chloro; p-Aminochlorobenzene; p-CA; p-Chloraniline; p-Chloroaniline; p-Chlorophenylamine; [ChemIDplus] UN2018

Category

Amines, Aromatic

Description

Colorless, white, or pale-yellow solid with a characteristic sweet odor; [HSDB] Light tan chips or crystalline solid; [MSDSonline]

Sources/Uses

Used as a chemical intermediate for dyes, pharmaceuticals, agricultural chemicals, and urea herbicides; [HSDB]

Comments

An eye irritant; Inhalation of high concentrations can cause methemoglobinemia; [ICSC] Toxic by ingestion, inhalation, or skin absorption; [CAMEO] May be a skin sensitizer based on animal studies; [CHEMINFO] May cause skin sensitization; [eChemPortal: ESIS] In the past, cases of severe methemoglobinemia were reported in workers manufacturing this chemical; Evidence of liver and kidney injury in high-dose animal experiments; 3-15% methemoglobin levels induced in rats at a dose of 13-40 mg/kg; [HSDB] An irritant; May cause skin sensitization; Effects in high-dose animal studies include convulsions, methemoglobinemia, and cyanosis; [MSDSonline] Danger of cutaneous absorption; Danger of skin sensitization; [MAK]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

0.027 mm Hg

LC50 (rat) = 2,340 mg/m3/4h

Explanatory Notes

Flash point = 120-123 deg C; [ICSC] The Guide in the Emergency Response Guidebook is for "Chloroanilines, solid." VP from ChemIDplus;

Yes

MetHgb is primary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Methemoglobinemia, acute