Acetanilide
Agent Name
Acetanilide
CAS Number
103-84-4
Formula
C8-H9-N-O
Major Category
Nitrogen Compounds
Synonyms
AN; Acetamide, N-phenyl-; Acetamidobenzene; Acetanil; Acetanilid; Acetic acid amide, N-phenyl-; Acetic acid anilide; Acetoanilide; Acetylaminobenzene; Acetylaniline; Aniline, N-acetyl-; Antifebrin; Benzenamine, N-acetyl-; N-Acetylaniline; N-Phenylacetamide; Phenalgene; Phenalgin; [ChemIDplus]
Category
Other Aromatics (Nitrogen)
Description
White odorless solid; [Hawley] White to gray solid; Sensitive to prolonged contact with air; [CAMEO] Off-white chips; [Alfa Aesar MSDS]
Sources/Uses
Used in the manufacture of camphor, penicillin, sulfa drugs, and dyes; Also used as a stabilizer for hydrogen peroxide, an additive to cellulose ester varnishes, a rubber accelerator, an antiseptic, a plasticizer, and a veterinary analgesic and antipyretic agent; [HSDB]
Comments
Heavy or repeated exposure may produce methemoglobinemia, CNS depression, circulatory collapse, and contact dermatitis in humans; Causes methemoglobinemia in high-dose animal studies; Mutagenic in micronucleus assay with mice; Emergency treatment: "Phenacetin"; Phenacetin was used as a pain-relieving drug, but has not been available in the US since 1983. Can cause methemoglobinemia after ingestion >1 gram/day; Phenacetin can cause renal papillary necrosis following ingestion of large doses for years; [HSDB] An irritant; May cause contact dermatitis, eczematous skin eruptions, anemia, and cyanosis; [CAMEO] An allergen; May cause eczematous dermatitis, methemoglobinemia, and cyanosis; [EPA OHM/TADS] Causes acute tubular necrosis and methemoglobinemia in oral toxic-dose exposures in humans; [RTECS] An irritant; May cause serious eye injury; Harmful if swallowed; [Aldrich MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
0.00122 mm Hg
Explanatory Notes
Flash point = 169 deg C; [HSDB]
NFPA
must be preheated
Adverse Effects
Skin Sensitizer
Yes
Methemoglobinemia
MetHgb is secondary toxic effect
Nephrotoxin
Yes
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: