Carbonyl fluoride
Agent Name
Carbonyl fluoride
CAS Number
353-50-4
Formula
C-F2-O
Major Category
Toxic Gases & Vapors
Synonyms
Carbon difluoride oxide; Carbon fluoride oxide (COF2); Carbon oxyfluoride (COF2); Carbonic difluoride; Carbonyl difluoride; Carbonyl fluoride; Carbonyl oxyfluoride; Difluoroformaldehyde; Difluorooxomethane; Fluophosgene; Fluoroformyl fluoride; Fluorophosgene; [ChemIDplus] UN2417
Category
Acid Halides
Description
Colorless gas with a pungent and very irritating odor; Note: Shipped as a liquefied compressed gas; [NIOSH]
Sources/Uses
Used in organic synthesis; generated from the thermal degradation of fluoropolymers, e.g., polytetrafluoroethylene (PTFE) and polyfluoroethylenepropylene; [ACGIH]
Comments
Liquid is a severe skin irritant; [CHRIS] Toxic effects from the liberation of fluoride by hydrolysis; causes pulmonary edema in animals exposed to lethal concentrations and liver and kidney damage in subchronic studies; "Critical Effects" are irritation; bone; fluorosis. [ACGIH] Possible frostbite from contact with liquid; [NIOSH] See "FLUORIDES."
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Insufficient data
TIH
Yes
TLV (ACGIH)
2 ppm
STEL (ACGIH)
5 ppm
Lethal Concentration
LC50 (rat) = 360 ppm/1h
Reference Link #2
Adverse Effects
Toxic Pneumonitis
Yes
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: