Chloroacetyl chloride
Agent Name
Chloroacetyl chloride
CAS Number
79-04-9
Formula
C2-H2-Cl2-O
Major Category
Toxic Gases & Vapors
Synonyms
Acetyl chloride, chloro-; Chloracetyl chloride; Chlorid kyseliny chloroctove [Czech]; Chloroacetic acid chloride; Chloroacetic chloride; Chlorure de chloracetyle [French]; Monochloroacetyl chloride; [ChemIDplus] UN1752
Category
Acid Halides
Description
Colorless to yellowish liquid with a strong, pungent odor; [NIOSH]
Sources/Uses
Used in organic synthesis; [ACGIH]
Comments
Liquid causes second or third degree burns after short contact; [CHRIS] Corrosive to skin; [Quick CPC] Hydrolysis of chloroacetyl chloride yields chloroacetic acid and hydrogen chloride gas. It causes "clinical and pathologic evidence of respiratory effects" at the lowest concentrations tested in experimental animals; [ACGIH] A lachrymator; [HSDB] A corrosive substance that can cause pulmonary edema; [ICSC]
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Yes
TIH
Yes
TLV (ACGIH)
0.05 ppm
Dangerous When Wet
Yes
STEL (ACGIH)
0.15 ppm
IDLH (NIOSH)
1.3 ppm
Vapor Pressure
25.2 mm Hg
Lethal Concentration
LC50 (rat) = 660 ppm/1h
Explanatory Notes
Some “Water Reactive Materials” are also TIH materials themselves: Chloroacetyl chloride; [ERG 2016] VP from ACGIH;
Reference Link #2
NFPA
will not burn
ERPG-1
0.05 ppm
ERPG-2
0.5 ppm
ERPG-3
10 ppm
Adverse Effects
Lachrymator
Yes
Toxic Pneumonitis
Yes
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: