Chlorobromomethane

Synonyms

Bromochloromethane; Chloromethyl bromide; Fluorocarbon 1011; Halon 1011; Methane, bromochloro-; Methylene chlorobromide; Mil-B-4394-B; Mono-chloro-mono-bromo-methane; [ChemIDplus] UN1887

Category

Chlorofluorocarbons

Description

Colorless to pale-yellow liquid with a chloroform-like odor; Note: May be used as a fire extinguishing agent; [NIOSH]

Sources/Uses

Used in fire extinguishers; [ACGIH]

Comments

In animal studies, causes reversible liver injury, narcosis, and anesthesia; Fire fighters exposed to high concentrations lost consciousness. [ACGIH]

See CHLOROFLUOROCARBONS

Biomedical References

Insufficient data

200 ppm

200 ppm

2000 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: Patty [1963] reported that light narcosis could be produced in animals at 3,000 ppm, and pulmonary edema and deaths during exposure at 27,000 ppm; delayed deaths occurred after exposure to 20,000 ppm [Comstock et al. 1953]. Patty [1963] also reported that guinea pigs survived 1­hour exposures but 1 of 3 guinea pigs died after 2­hour exposures to 8,000 to 10,000 ppm [Matson and Dufour 1948]. . . . Basis for revised IDLH: The revised IDLH for chlorobromomethane is 2,000 ppm based on acute inhalation toxicity data in animals [Comstock et al. 1952; Comstock and Oberst 1953; Matson and Dufour 1948]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

142 mm Hg

397 ppm

LCLo (rat) = 28,800 ppm/15 min

Explanatory Notes

Odor threshold from ACGIH; VP from HSDB;

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect