Aminopterin

Synonyms

4'-Amino-folsaeure; 4'-Desoxy-4'-aminofolsaeure; 4-Amino pteroylglutamic acid; 4-Amino-4-deoxypteroylglutamate; 4-Amino-4-desoxy-pteroylglutaminsaeure; 4-Amino-PGA; 4-Aminofolic acid; 4-Aminopteroylglutamic acid; A-Ninopterin; APGA; Aminopteridine; Aminopterine; Aminopterinum; Folic acid, 4-amino-; Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-, L-; Kyselina 4-aminolistova [Czech]; Kyselina 4-aminopteroylglutamova [Czech]; Kyselina N-(p-((2,4-diamino-6-pteridinyl)methyl)benzoyl)-L(+)-glutamova [Czech]; Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)amino)benzoyl)-L(+)-glutamova [Czech]; L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-; N-(1-((2,4-Diamino-6-pteridinylmethyl)amino)benzoyl)glutaminsaeure; N-(4-(((2,4-Diamino-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; N-(4-(((2,4-Diamino-6-pteridyl)-methyl)amino)benzoyl)-L-glutamic acid; Pteramina [Czech]; [ChemIDplus]

Category

Rodenticides

Description

Orange-yellow solid; [HSDB]

Sources/Uses

Used as a rodenticide and medicine; [Hawley] Formerly used in the treatment of childhood leukemia; [HSDB]

Comments

A folate antagonist; When used as a medication during pregnancy, increases the risk of abortions and malformations; Bone marrow toxicity: hypoplasia of all elements including leukopenia and thrombocytopenia; [HSDB] Increases risk of malformations if taken during pregnancy; [REPROTOX] May cause irritation; Targets the blood; [MSDSonline]

Biomedical References

Aplastic anemia

Yes

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)