Apholate

Synonyms

1,3,5,2,4,6-Triazatriphosphorine, 2,2,4,4,6,6-hexakis(1-aziridinyl)-2,2,4,4,6,6-hexahydro-; 1-Aziridinylphosphonitrile trimer; 2,2,4,4,6,6-Hexahydro-2,2,4,4,6,6-hexakis(1-aziridinyl)-1,3,5,2,4,6-triazatriphosphorine; 2,2,4,4,6,6-Hexakis(1-aziridinyl)-2,2,4,4,6,6-hexahydro-1,3,5,2,4,6-triazatriphosphorine; 2,2,4,4,6,6-Hexakis(1-aziridinyl)cyclotriphosphaza-1,3,5-triene; APN; Afolat [Czech]; Aziridine, 1,3,5,2,4,6-triazatriphosphorine derivative; CB 40068; Hexa(1-aziridinyl)-1,3,5-phosphotriazine; Hexa(1-aziridinyl)triphosphotriazine; Hexakis (1-aziridinyl)phosphonitrilate; Hexakis(aziridinyl)phosphotriazine; Hexakis-(1-aziridinyl)phosphonitrile; Myko 63; Olin MO. 2174; PN6; Pholate; SQ 8388; [ChemIDplus]

Category

Other Insecticides

Description

Solid; [Merck Index]

Sources/Uses

Used as an insect chemosterilant (prevents reproduction in certain insects); [HSDB]

Comments

In high-dose animal studies, causes hepatitis and kidney injury; Causes ataxia and paralysis in birds; [RTECS] Mechanism appears to be as alkylating agent on genetic material; Causes marked leukopenia in mammals within 24 hours of injection; Mutagenic in Neurospora crassa; [HSDB]

Biomedical References

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)