Azaserine
Agent Name
Azaserine
CAS Number
115-02-6
Formula
C5-H7-N3-O4
Major Category
Biological Agents
Synonyms
AZS; Acetic acid, diazo-, ester with serine; Azaserin; Azaserina [INN-Spanish]; Azaserinum [INN-Latin]; CL 337; CN 15757; CN-15,757; Diazoacetate (ester) L-serine; L-Azaserine; L-Serine, diazoacetate (ester); L-beta-(Diazoacetoxy)alanin; O-Diazoacetyl-L-serine; P-165; Serine, diazoacetate (ester), L-; [ChemIDplus] UN3462
Category
Bacterial Toxins
Description
Light yellow-green solid; [Merck Index] Faintly yellow powder; [MSDSonline]
Sources/Uses
Antitumor/antibiotic produced by Streptomyces sp; Used to induce pancreatic cancer in laboratory animals; [Merck Index] Medical and veterinary applications include: antibiotic, antifungal, antineoplastic, and immunosuppressive; Not commercially produced in the US; [HSDB]
Comments
An amino acid antagonist that inhibits the synthesis of proteins and nucleic acids; Causes fatty liver and hepatic necrosis; Emergency treatment: Symptomatic drug ingestion; [HSDB] May cause irritation; Targets kidneys, liver, and bone marrow; [MSDSonline]
Biomedical References
Exposure Assessment
Vapor Pressure
1.53E-10 mm Hg
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Possible (2b)
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.