2,2-Bis(bromomethyl)-1,3-propanediol

Synonyms

1,3-Dibromo-2,2-dimethylolpropane; 1,3-Propanediol, 2,2-bis(bromomethyl)-; 2,2-Dibromomethyl-1,3-propanediol; Dibromoneopentyl glycol; Dibromopentaerythritol; FR 1138; Pentaerythritol dibromide; Pentaerythritol dibromohydrin; 2,2-Bis(bromomethyl)propane-1,3-diol; [ChemIDplus]

Category

Halogenated Alcohols

Description

Off-white hygroscopic solid; [CAMEO]

Sources/Uses

Used as a reactive flame retardant for epoxy, polyester, and urethane foams and a chemical intermediate for flame retardants; [HSDB]

Comments

A skin, eye, and mucous membrane irritant; May cause liver damage and corneal injury; [CAMEO] Observations in a high-dose lifetime feeding study of rats include degenerative changes to liver and eyes, but no oncogenic reaction; A two year feeding study with rats produced increase in neoplasm frequency in various tissues and organs; [HSDB] Effects observed in 13 week oral studies with mice and rats include histopathological changes to kidneys and urinary bladder; Rats fed 100 mg/kg bw throughout their lifetime exhibited degeneration of the liver, eye, and higher frequency of thyroid retention cyst formation; No adverse effects on sperm parameters or estrous cycle observed in 13 week feeding studies with rats and mice; A decrease in female reproductive capacity was shown in a continuous breeding study with mice; Some evidence of mutagenicity; “Sufficient evidence” of carcinogenicity in laboratory animals; [IARC]

Biomedical References

1.3E-05 mm Hg

0.2 mg/m3

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Anticipated human carcinogen

Other Information

No other related information on this agent was found.