Dimethyl carbamoyl chloride

Synonyms

(Dimethylamino)carbonyl chloride; Carbamic chloride, dimethyl-; Carbamoyl chloride, dimethyl-; Carbamyl chloride, N,N-dimethyl-; Chlorid kyseliny dimethylkarbaminove [Czech]; Chloroformic acid dimethylamide; Dimethyl carbamoyl chloride; Dimethylamid kyseliny chlormravenci [Czech]; Dimethylcarbamic acid chloride; Dimethylcarbamic chloride; Dimethylcarbamidoyl chloride; Dimethylcarbamoyl chloride; Dimethylcarbamyl chloride; Dimethylchloroformamide; Dimethylkarbamoylchlorid [Czech]; N,N-Dimethylcarbamic acid chloride; N,N-Dimethylcarbamidoyl chloride; N,N-Dimethylcarbamoyl chloride; N,N-Dimethylcarbamyl chloride; TL 389v; [ChemIDplus] DMCC; {ACGIH] UN2262

Category

Acid Halides

Description

Clear, colorless liquid; [NIOSH] Noxious odor; [ACGIH]

Sources/Uses

Used to manufacture carbamate pesticides, dyes, and drugs; Exposed workers include "pesticide formulators, dye makers, and pharmaceutical workers." [ACGIH]

Comments

Liquid causes second or third degree burns after short contact. [CHRIS] A lachrymator; Inhalation exposure to HCl may cause chemical pneumonitis; [HSDB] DMCC reacts with tissue at the point of contact. DMCC hydrolyzes to dimethylamine, CO2, and HCl. Animals in feeding studies develop liver hemorrhages. “Sprague-Dawley rats were exposed by inhalation 6 hours/day, 5 days/week for 6 weeks at 0.5, 1.0, or 2.0 ppm DMCC in an exposure chamber and held without further exposure for up to 2 years. A dose-response relationship for both the development of morphological lesions and for tumor incidences of the nasal cavity and nasopharyngeal areas was seen, ranging from 89% tumor incidence at 2 ppm to 4% incidence at 0.5 ppm. No tumors in these regions were reported in the controls.” [ACGIH]

Biomedical References

Yes

0.005 ppm

1.95 mm Hg

LC50 (rat) = 180 ppm/ 6h

Explanatory Notes

Flash point: not available; [ACGIH] VP from HSDB;

Yes

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Probable (2a)

Anticipated human carcinogen

Suspected Human

Other Information

No other related information on this agent was found.