Dimethyl carbamoyl chloride

Agent Name
Dimethyl carbamoyl chloride
CAS Number
Major Category
Toxic Gases & Vapors
Dimethyl carbamoyl chloride formula graphical representation
(Dimethylamino)carbonyl chloride; Carbamic chloride, dimethyl-; Carbamoyl chloride, dimethyl-; Carbamyl chloride, N,N-dimethyl-; Chlorid kyseliny dimethylkarbaminove [Czech]; Chloroformic acid dimethylamide; Dimethyl carbamoyl chloride; Dimethylamid kyseliny chlormravenci [Czech]; Dimethylcarbamic acid chloride; Dimethylcarbamic chloride; Dimethylcarbamidoyl chloride; Dimethylcarbamoyl chloride; Dimethylcarbamyl chloride; Dimethylchloroformamide; Dimethylkarbamoylchlorid [Czech]; N,N-Dimethylcarbamic acid chloride; N,N-Dimethylcarbamidoyl chloride; N,N-Dimethylcarbamoyl chloride; N,N-Dimethylcarbamyl chloride; TL 389v; [ChemIDplus] DMCC; {ACGIH] UN2262
Acid Halides
Clear, colorless liquid; [NIOSH] Noxious odor; [ACGIH]
Used to manufacture carbamate pesticides, dyes, and drugs; Exposed workers include "pesticide formulators, dye makers, and pharmaceutical workers." [ACGIH]
Liquid causes second or third degree burns after short contact. [CHRIS] A lachrymator; Inhalation exposure to HCl may cause chemical pneumonitis; [HSDB] DMCC reacts with tissue at the point of contact. DMCC hydrolyzes to dimethylamine, CO2, and HCl. Animals in feeding studies develop liver hemorrhages. “Sprague-Dawley rats were exposed by inhalation 6 hours/day, 5 days/week for 6 weeks at 0.5, 1.0, or 2.0 ppm DMCC in an exposure chamber and held without further exposure for up to 2 years. A dose-response relationship for both the development of morphological lesions and for tumor incidences of the nasal cavity and nasopharyngeal areas was seen, ranging from 89% tumor incidence at 2 ppm to 4% incidence at 0.5 ppm. No tumors in these regions were reported in the controls.” [ACGIH]
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
0.005 ppm
Vapor Pressure
1.95 mm Hg
Lethal Concentration
LC50 (rat) = 180 ppm/ 6h
Explanatory Notes
Flash point: not available; [ACGIH] VP from HSDB;

Adverse Effects

Toxic Pneumonitis
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Skin burns
IARC Carcinogen
Probable (2a)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Suspected Human

Diseases, Processes, and Activities Linked to This Agent

Other Information
No other related information on this agent was found.