Dimethyl sulfate

Agent Name
Dimethyl sulfate
CAS Number
Major Category
Toxic Gases & Vapors
Dimethyl sulfate formula graphical representation
DMS (methyl sulfate); Dimethyl monosulfate; Dimethyl sulfate; Dimethyl sulphate; Dimethylester kyseliny sirove [Czech]; Dimethylsulfaat [Dutch]; Dimethylsulfat [Czech]; Dimetilsolfato [Italian]; Dwumetylowy siarczan [Polish]; Methyl sulfate; Methyl sulfate (VAN); Methyle (sulfate de) [French]; Sulfate de dimethyle [French]; Sulfate dimethylique [French]; Sulfato de dimetilo [Spanish]; [ChemIDplus] UN1595
Other Toxic Gases & Vapors
Colorless, oily liquid with a faint, onion-like odor; [NIOSH]
Used as a methylating agent in the synthesis of many organic compounds; [ACGIH]
Dimethyl sulfate causes blistering and ulceration of the skin. In cases of industrial poisoning, workers experienced burning eyes first and then respiratory symptoms, including irritation of the nose and throat, chest pain, cough, and dyspnea. Persistent abnormalities in liver function following exposure have been reported. Death is due to circulatory failure. In the presence of water vapor, dimethyl sulfate readily hydrolyzes into methanol and sulfuric acid. [ACGIH] Causes second or third degree burns after short skin exposure; [CHRIS] In a textile plant using dimethyl sulfate to produce surfactants, air levels were low but workers in one building had high blood levels secondary to skin absorption. [Schettgen T, Broding HC, Angerer J, Drexler H. Dimethyl sulphate; a hidden problem in occupational medicine. Occup Environ Med 2004;61:73-75] Dimethyl sulfate causes no known injury to the liver in experimental animals or humans. [Zimmerman, p. 368] A corrosive substance that can cause pulmonary edema; Can cause effects on the liver, kidneys, and CNS; [ICSC]
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
0.1 ppm
1 ppm
7 ppm
Excerpts from Documentation for IDLHs
The chosen IDLH is based on the statement by Patty [1963] that a 20­minute exposure to 13 ppm caused severe symptoms in monkeys and a 20­minute exposure to 75 ppm resulted in the LC50 for guinea pigs [Ghiringhelli et al. 1957; Ghiringhelli and Sironi 1958].
Vapor Pressure
0.677 mm Hg
Lethal Concentration
LC50 (rat) = 45 mg/m3/4 hr
Explanatory Notes
Flash point = 182 deg F; VP from HSDB;
Reference Link #2
high ambient temp required

Adverse Effects

Toxic Pneumonitis
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Skin burns
IARC Carcinogen
Probable (2a)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Confirmed Animal

Diseases, Processes, and Activities Linked to This Agent


Occupational diseases associated with exposure to this agent: