Hexamethylphosphoric triamide
Agent Name
Hexamethylphosphoric triamide
Alternative Name
Hexamethyl phosphoramide
CAS Number
680-31-9
Formula
C6-H18-N3-O-P
Major Category
Other Classes
Synonyms
Eastman Inhibitor HPT; HMPA; HMPT; HMPTA; Hempa; Hexametapol; Hexamethyl phosphoramide; Hexamethylfosforamid [Czech]; Hexamethylorthophosphoric triamide; Hexamethylphosphoramide; Hexamethylphosphoric acid triamide; Hexamethylphosphoric triamide; Hexamethylphosphorotriamide; Hexamethylphosphotriamide; N,N,N,N,N,N-Hexamethylphosphoric triamide; Phosphoric acid hexamethyltriamide; Phosphoric hexamethyltriamide; Phosphoric triamide, hexamethyl-; Phosphoric tris(dimethylamide); Phosphoryl hexamethyltriamide; Tris(dimethylamino)phosphine oxide; Tris(dimethylamino)phosphorus oxide; Tris-(dimethylamid) kyseliny fosforecne [Czech]; [ChemIDplus]
Category
Phosphorus Compounds
Description
Clear, colorless liquid with an aromatic or mild, amine-like odor. [Note: A solid below 43 degrees F.]; [NIOSH]
Sources/Uses
Used as a solvent for aromatic polyamide fibers; also used as a catalyst, stabilizer, and additive for polymers and resins; [ACGIH]
Comments
A TLV is not recommended because the absence of data. Rats suffer kidney injury and death after repeated inhalation exposures. HMPA is carcinogenic in animals. The TLV Basis is upper respiratory tract cancer. [ACGIH] May have effects on the lungs, kidneys, and bone marrow; [ICSC]
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Yes
Vapor Pressure
0.03 mm Hg
Lethal Concentration
LCLo (rat) = 2,920 mg/m3/4h
Explanatory Notes
Carcinogen--No TLV; NIOSH REL = lowest feasible conc. Flash point = 222 deg F;
Adverse Effects
Nephrotoxin
Yes
IARC Carcinogen
Possible (2b)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Confirmed Animal
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: