Caffeine

Agent Name
Caffeine
CAS Number
58-08-2
Formula
C8-H10-N4-O2
Major Category
Biological Agents
Caffeine formula graphical representation
Synonyms
1,3,7-Trimethyl-2,6-dioxopurine; 1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione; Alert-Pep; Anhydrous caffeine; Cafamil; Cafecon; Cafeina; Caffedrine; Caffein; Caffeina [Italian]; Caffeine (natural); Caffeine, anhydrous; Caffeine, synthetic; Caffine; Cafipel; Coffein [German]; Coffeine; Coffeinum; Dexitac; Eldiatric C; Guaranine; Hycomine; Kofein [Czech]; Koffein [German]; Mateina; Methyltheobromine; NO-Doz; Nix Nap; Nodaca; Organex; Quick-Pep; Refresh'n; Stim; Thein; Theine; Theobromine, 1-methyl-; Theophylline, 7-methyl; Tirend; Tri-Aqua; Vivarin; Wigraine; Xanthine, 1,3,7-trimethyl; [ChemIDplus] UN1544
Category
Plant Toxins
Description
Odorless solid; Slightly soluble in water (1 g/ 46 mL); [Merck Index] White solid; Slightly soluble in water; [MSDSonline]
Sources/Uses
Occurs naturally in tea leaves, coffee beans, cocoa beans, mate leaves, guarana paste, and kola nuts; [Merck Index] Used in beverages, cardiac and respiratory stimulants, and diuretics; [HSDB] Also used in cosmetics; [eChemPortal: SIDSUNEP]
Comments
A diuretic and CNS and heart stimulant; [ICSC] Repeated intraperitoneal doses are toxic to liver in mice; Subcutaneous dose causes convulsions in mice with LD50 of 81 mg/kg; [RTECS] Ingestion of 35 mg/kg is moderately toxic in children. Coffee contains 50-200 mg and tea 40-100 mg of caffeine per cup. Acute caffeine poisoning can cause nausea, vomiting, delirium, seizures, hypokalemia, and fatal arrhythmias. [Olson, p. 170]
Biomedical References

Exposure Assessment

Vapor Pressure
7.3E-09 mm Hg
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Alkaloids, solid, n.o.s. (poisonous)."
Half Life
Elimination 1/2 life in adults = 2.5-4.5 hours; [Reference #1]

Adverse Effects

Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Not classifiable

Diseases, Processes, and Activities Linked to This Agent

Other Information
No other related information on this agent was found.