Calotropin
Agent Name
Calotropin
CAS Number
1986-70-5
Formula
C29-H40-O9
Major Category
Biological Agents
Synonyms
Card-20(22)-enolide, 14-hydroxy-19-oxo-3,2-((tetrahydro-3,4-dihydroxy-6-methyl-2H-pyran-2,3-diyl)bis(oxy))-, (2alpha(2S,4S,6R),3beta,5alpha)-; Cardenolide; Pecilocerin A; Pekilocerin A; [ChemIDplus]
Category
Plant Toxins
Description
Solid; Soluble in water; [Merck Index]
Sources/Uses
African arrow poison isolated from milk sap of Calotropis procera; [Merck Index]
Comments
Emergency treatment: "Plants- cardiac glycosides"; [HSDB] Intraperitoneal LD50 (mouse) = 9800 ug/kg; Causes ataxia, somnolence, and seizures at lethal doses; [RTECS] Milkweed (Asclepias spp) contains cardiac glycosides; [Olson, p. 385] Milkweed (Asclepias spp) contains cardenolides that are cardiac toxins; [Goldfrank, p. 1538] See "Calotoxin."
Biomedical References
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.