Propyleneimine

Agent Name
Propyleneimine
Alternative Name
2-Methylaziridine
CAS Number
75-55-8
Formula
C3-H7-N
Major Category
Nitrogen Compounds
Propyleneimine formula graphical representation
Synonyms
1,2-Propyleneimine; 1,2-Propylenimine; 2-Methylazacyclopropane; 2-Methylaziridine; 2-Methylethylenimine; Aziridine, 2-methyl-; Methylaziridine; Methylethylenimine; Propilenimina [Spanish]; Propylene imine; Propyleneimine; Propylenimine; [ChemIDplus] UN1921
Category
Other Nitrogen Compounds
Description
Colorless, oily liquid with an ammonia-like odor; [NIOSH]
Sources/Uses
Used as an intermediate in the rubber and pharmaceutical industries; Used as a modifier and monomer in advanced composites; [HSDB]
Comments
At higher concentrations, may cause blistering and necrosis of the skin; Toxicity is similar to that of ethyleneimine; Causes severe injuries to the kidneys (tubular necrosis) in acute animal experiments and tumors in chronic ones; [HSDB] An irritant of the skin, eyes, and respiratory tract; [ICSC] Suspected germ cell mutagen (3B); [MAK] Propyleneimine, stabilized (UN1921) has warning of explosive polymerization; [ERG 2016]
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
Yes
TLV (ACGIH)
0.2 ppm
STEL (ACGIH)
0.4 ppm
PEL (OSHA)
2 ppm
IDLH (NIOSH)
100 ppm
Excerpts from Documentation for IDLHs
It has been reported that rats survived a 2­hour exposure to 500 ppm and guinea pigs survived a 30­minute exposure to 500 ppm [Carpenter et al. 1948].
Vapor Pressure
140 mm Hg
Lethal Concentration
LCLo (rat) = 500 ppm/4 hr
Explosive Polymerization
Yes
Explanatory Notes
Flash point = -3 deg C; VP from HSDB;

Adverse Effects

Toxic Pneumonitis
Yes
Nephrotoxin
Yes
Dermatotoxin
Skin burns
IARC Carcinogen
Possible (2b)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Confirmed Animal

Diseases, Processes, and Activities Linked to This Agent

Processes

Industrial Processes with risk of exposure: