p-Toluenesulfonyl chloride

Synonyms

4-Methylbenzenesulfonyl chloride; 4-Toluenesulfonic acid, chloride; 4-Toluenesulfonyl chloride; Benzenesulfonyl chloride, 4-methyl-; Toluenesulfonyl chloride (VAN); Tosyl chloride; p-Methylbenzenesulfonyl chloride; p-Toluenesulfochloride; p-Toluenesulfonic acid chloride; p-Toluenesulphonyl chloride; p-Tolylsulfonyl chloride; p-Tosyl chloride; para-Toluenesulfochloride; para-Toluenesulfonyl chloride; [ChemIDplus] PTSC; [AIHA] UN3096

Category

Acid Halides

Description

A white to gray solid; [CAMEO] Hygroscopic; [eChemPortal: SIDSUNEP] White or light yellow crystalline solid; [MSDSonline]

Sources/Uses

Used to make other organic chemicals; [Hawley] Used to make food additives, foaming agents for plastics and rubber, riboflavin, antithrombotic drugs, and dye condensing agents; [eChemPortal: SIDSUNEP]

Comments

A skin, eye, and respiratory tract irritant; [HSDB] Reacts violently with water evolving hydrochloric acid; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline] Slowly hydrolyzes to strong acids (HCl and p-toluenesulfonic acid); Severely irritating to skin and eyes in animal testing; [AIHA] Contact dermatitis documented in a chemist; [Kanerva, p. 1841]

Reference Link #1

Biomedical References

Explanatory Notes

VP = 0.5 mm Hg at 75 deg C; [ChemIDplus] The Guide in the Emergency Response Guidebook is for "Corrosive solid, water-reactive, n.o.s."

Ceiling = 5 mg/m3

Yes

Yes

Skin burns

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic